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Paper in Mutagenesis: Extended treatment with recovery improves results in the peripheral blood lymphocyte micronucleus assay

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EDITOR’S CHOICE

Inclusion of an extended treatment with recovery improves the results for the human peripheral blood lymphocyte micronucleus assay

Mutagenesis, Volume 34, Issue 3, May 2019, Pages 217–237, https://doi.org/10.1093/mutage/gez011
Read the article here.

Upcoming In Vitro Toxicology Society Workshop

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The IVTS presents a workshop on the applicability of in silico models to support in vitro studies. This workshop will be held on the 21st October 2019 in Leeds, UK, hosted by Lhasa Ltd. Registration is £40 and includes one year’s membership to the IVTS.

Click here for more information and to register.

 

New Paper: Are All Bacterial Strains Required by OECD Needed?

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Are All Bacterial Strains Required by OECD Mutagenicity Test Guideline TG471 Needed?

Williams, Richard , DeMarini, David M. , et al Mutation Research/Genetic Toxicology and Environmental Mutagenesis August 2019

Read the latest paper in Mutation Research. Genetic Toxicology and Environmental Mutagenesis

Highlights

Salmonella TA1535 detected few mutagens not detected by Salmonella TA100.
Salmonella TA97 should be used in preference to Salmonella TA1537.
Escherichia coli WP2 uvrA pKM101 is preferred to WP2 uvrA and Salmonella TA102.
Salmonella TA98 & TA100 detected 93% of mutagens detected by all the TG471 strains.

DOI: 10.1016/j.mrgentox.2019.503081

ITTP PhD studentship with AstraZeneca and Imperial College, London

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“Understanding the role of cohesin and the impact of structural variation on gene expression regulation in the 3D genome”

A fully funded ITTP PhD opportunity from the MRC, in conjunction with Imperial College, London and AstraZeneca, Cambridge to start September 2019.

See the full advert here.

Informal enquiries to Professor Nigel Gooderham (n.gooderham@imperial.ac.uk) or Dr Rhiannon David (rhiannon.david@astrazeneca.com).

Stipend: Current MRC rates plus an Imperial College/AstraZeneca supplement (4 years). Tuition fees paid. Start date Sept 2019.

Please send applications, including a CV and personal statement to: n.gooderham@imperial.ac.uk or rhiannon.david@astrazeneca.com

Deadline for applications 31st July 2019. 

Interviews to be held during August 2019 at AstraZeneca, Cambridge.

 

UKEMS Small Grants Scheme for Feasibility or Pilot Studies 2019

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The UKEMS Small Grants Scheme for Feasibility or Pilot Studies is now open!

The small grants scheme is aimed to promote research into key areas of relevance to UKEMS. The awards are primarily aimed to facilitate junior investigators establishing their careers. We will also consider awards to establish pilot/feasibility studies for preliminary data, with a view to obtaining further grant funding.

Funding is available for a period of up to 12 months and applications should not exceed £5000.

The deadline for applications is Friday 17th May 2019.

Further information and details on how to apply can be found on the UKEMS website: http://ukems.org.uk/about/bursaries/ukems-small-grants-scheme/

Save the Date! IGG Annual Meeting 19th-20th June 2019

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Save the date! This year’s IGG Annual Meeting will be held from the 19th – 20th June 2019 at the Deansgate Hilton in Manchester. This meeting is sponsored by Gentronix and will be on the theme “Regulatory Genetic Toxicology: Theory and Reality”. The meeting will start on the evening of the 19th with a keynote from David Kirkland on “Regulatory Assessment of Genotoxicity Data: Past, Present and Future” followed by drinks and bowl food, an excellent opportunity for networking and catching up with colleagues. The 20th will have half a day on “Regulatory Genetic Toxicology: Theory” covering new challenges including oligos and medical devices, while the afternoon will be interactive workshops on proof of exposure and when negative is equivocal. Download the Meeting Flyer for more information. There will be travel bursaries available as well as early bird registration fees and reduced rates for members of EEMGS and affiliated societies. Registration will open soon, so for now, Save the Date!

NC3Rs-Unilever PhD Studentship Launch Event

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NC3Rs-Unilever PhD Studentship Launch Event

 

On 2 April the NC3Rs are holding a launch event in central London to highlight a new collaboration with Unilever, who will be co-funding three of our PhD Studentship awards this year. The event will allow potential applicants to find out more about the scheme, network with fellow researchers and discuss ideas with staff from both Unilever and the NC3Rs.

The NC3Rs PhD Studentship awards embed the 3Rs into the training of graduate scientists from a broad range of scientific backgrounds. The joint NC3Rs-Unilever Studentships will focus on the following areas in the field of non-animal safety assessment:

  • Local exposure – microbiome, skin, lung
  • Clearance mechanisms – renal, liver metabolism
  • Repeat dosing
  • Non-animal models with a human focus

 

Attendees will have the opportunity to:

  • Hear from NC3Rs grant holders and Unilever researchers applying the 3Rs within the safety assessment field.
  • Learn about the PhD Studentship scheme and hear tips on how to apply.
  • Have a one-to-one with a member of NC3Rs or Unilever staff to discuss potential ideas.
  • Network with fellow researchers, potential collaborators and meet with Unilever and NC3Rs representatives.

 

To register for the event please complete the form on our events page, using your institutional email address by 27 March 2019. If you would like to book a one-to-one session, please state your interest in the “Other requirements” section or alternatively email events@nc3rs.org.uk. Please note these sessions will be allocated on a first come, first serve basis.

Further information on the PhD Studentship scheme can be found on the scheme webpage.

IGG at UKEMS 2019

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This year, UKEMS will hold a joint meeting with the BTS at Robinson College Cambridge from 15th – 17th April.

The BTS-UKEMS Congress 2019 programme has a strong speaker line-up, which hopes to draw a record number of delegates, all key members within the field of toxicology.

Registration is open.

Abstract submission is open, the deadline for submission is February 1st 2019.

To view the latest programme highlights, to register and for abstract submission click here.

UKEMS provides bursaries for students, postdoctoral and industrial members to attend the annual UKEMS conference. To apply, click here.

IGG will host a session at the meeting. Check our meeting page, Twitter and LinkedIn for updates.

We look forward to seeing you there!

IGG @ UKEMS 2018

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UKEMS 2018 will be held from September 2nd – 5th at Magdalen College, Oxford

The IGG have contributed to sessions at this year’s UKEMS meeting by selecting speakers on topics relevant to the industrial community. These include:

James Whitwell, Covance, Harrogate: Extended treatment with recovery is required for detection of certain chemicals in the human peripheral blood lymphocyte assay.

Amy Wilson, AstraZeneca, Cambridge: High content comparison of GeneTox responses in parent and p53 knock out cell lines.

Shareen Doak, Swansea University: 3D liver spheroids for genotoxicity testing.

Follow us on Twitter for live updates from the meeting.