All Posts By

admin

Aug 23
0

NUKEMS Virtual Symposium, 6th September 2021

By | Symposium | No Comments

NUKEMS will be hosting a Virtual Symposium, which will take place on the 6th September, between 9:30 am and 2:00 pm (BST).

This event will feature scientific talks and a virtual poster session (including prizes), plus the launch of the new Dr Eleanor Wilde Memorial Award, sponsored by her family and UKEMS. There is also an exciting keynote speaker, Professor Michael Fenech, who will speak about his career and advice for early career scientists.

The Virtual Symposium is free to attend for all UKEMS members and anyone working in a related field. The NUKEMS Committee would really appreciate the support of any supervisors within UKEMS, by encouraging their students/ new investigators (staff/ postdocs) to attend.

Please see follow this link for more information and details on how to register for the event.

Jun 18
5

The Richard Williams Memorial Award 2021

By | Awards | No Comments

The IGG are proud to support an award honouring the scientific contributions and memory of Dr. Richard Williams, set up by Lhasa. This award will support early career investigators within industry. The Richard Williams Memorial Award will include a certificate, travel, registration and accommodation expenses for attendance to the United Kingdom Environmental Mutagen Society (UKEMS) meeting.

Please share this message with colleagues and encourage all eligible young scientists to put themselves forward for this award. To apply, please send a title and abstract (max 300 words) to the IGG Committee (info@theigg.co.uk) by 30th September 2021.

Candidates should have completed their most recent degree a maximum of 5 years ago, and their research should have an obvious industrial interest or application.  However, the IGG Committee will have consider reasonable exceptions to these criteria on a case-by-case basis.  All candidates should be UK-based or affiliated with a UK based company or institution.

Note: In addition to Richard Williams awards entries, the IGG are also looking for short talks from early career scientists (even earlier career scientists!) to feature at our meeting.  This would particularly apply to current students, or those recently joining the field.  Again, topics with an industrial interest of application are preferred.

You can find out more about Rich and the award here.

May 26
0

NUKEMS Virtual Skills Workshop

By | Workshop | No Comments
NUKEMS Virtual Skills Workshop | 19th July 2021 | 09:30-16:00

NUKEMS have an exciting programme of events which we hope will really help our early career scientists. We also encourage active participation through the pre-submission of questions for certain sessions, and these question boxes can be found on our event website via the links on the attached poster. The event is open to UKEMS Members and any early career scientists within the field who would benefit from this event! We would like the UKEMS membership to share with any of their contacts who might be interested or who can share further. Thank you to UKEMS for their support.

NUKEMS VIRTUAL SKILLS WORKSHOP | 19th July 2021 | 09:30-16:00

NUKEMS skills workshop flyer

May 25
0

The First Richard Williams Memorial Award Winner

By | Awards, Meetings | No Comments

Last year, at our annual IGG meeting, we held the first Richard Williams Memorial Award honouring the scientific contributions and memory of Dr. Richard Williams, our past IGG committee member. This award was kindly sponsored by Lhasa and was set up to support early career investigators within industry. Supported by the IGG, The Richard Williams Memorial Award will sponsor one individual a year to attend and present at the United Kingdom Environmental Mutagen Society (UKEMS) meeting.

It is with huge excitement that today, we are able to introduce you to the first winner of the Richard Williams Memorial Award, Amy Wilson.

Amy is an Associate Principal Scientist within the Genetic Toxicology team at AstraZeneca. Learn more about Amy’s award-winning work, career to date, biggest inspiration and where you can see Amy present her work in Lhasa’s blog here.

Mar 24
0

Duplex Sequencing Webinar

By | Webinar | No Comments

Working from home? Keep up to date with the latest sequencing technology for mutation detection by joining a webinar on Thursday March 26th on Duplex Sequencing. To register, click here.

Title: Duplex Sequencing™ Technology: Transforming Safety Testing

Date: Thursday, March 26, 2020

Time: 11:00 AM Eastern Daylight Time

Duration: 1 hour

Speakers:

Bob Young, MS
Program Consultant and Study Director, In Vivo Mutation
Merck KGaA, Darmstadt, Germany

Jesse Salk, MD, PhD
CEL, CSO and Founder
TwinStrand Biosciences

In this webinar, you will learn about:

  • Duplex Sequencing™ technology unmatched sensitivity and accuracy in NGS applications
  • Duplex technology applications in identification of carcinogenic chemicals
  • Global efforts to evaluate and adopt Duplex Sequencing™ technology for regulatory submission
  • Applications in drug and chemical safety assessment

Detailed description:

Duplex Sequencing™ technology is a new error-corrected NGS method that improves sequencing accuracy 100,000-fold. This increase in accuracy opens the door to significant reductions in time spent in drug development, allowing measurement of a compound’s carcinogenic risk months or even years earlier than current methods. DS technology now permits early measurement of ultra-rare new mutants. We will discuss the technology, clinical applications and then explore nonclinical safety assessment applications. Mouse and rat mutation data will be presented from various mutagens, tissues and genes. Mutant frequency data and mutational “fingerprint” data will be discussed in context of human tumors. Plans for collaborative qualification through the HESI Genetic Toxicology Technical Committee will be discussed.

Jan 17
0

Gentronix Job Vacancy: In vitro mammalian gene mutation Study Director

By | Job advert | No Comments

Job vacancy at Gentronix for an in vitro mammalian gene mutation Study Director

Job Reference: GTXHPRT2020 

Opening Date – 10th January 2020
Closing Date – 10th February 2020

Gentronix is seeking an enthusiastic and highly motivated scientist to join our in vitro genetic toxicology team as an in vitro mammalian gene mutation Study Director. The team is growing due to planned services expansion and needs a committed and organised individual to help drive the expansion of the in vitro genetic toxicology service offering. The role will require good integration into the existing team and close working with the other Study Directors. For the successful applicant, the role presents opportunities to build-on and further develop their skills as a toxicologist within a CRO environment, with scope for further career progression within a growing and successful business.

For full job specifications and how to apply, click here.

Nov 11
0

HESI GTTC Comet Assay Survey

By | Uncategorized | No Comments

The Health and Environmental Sciences Institute Genetic Toxicology Technical Committee (HESI GTTC) needs your help.  We are developing a project to improve the clarity and application of OECD TG 489 (In Vivo Mammalian Alkaline Comet) for applications across most industries.  But to accomplish this, we need to identify the most critical issues and concerns to address.  So included below is a link for our survey that will help us gather this information.  If you have been considering, conducting, requesting, reviewing , or even avoiding regulated in vivo comet assay studies, please complete our survey.  And if you have any colleagues that may be willing to contribute their input, we would really appreciate it if you could forward to them the link for our survey. Regardless of one’s industry or level of experience with the comet assay, everyone’s input is very critical to this process.  The survey will only take a few minutes and we are asking participants to please complete it by the end of December 2019.  Please note that every participant will be informed of the results of this survey and the GTTC plans to address the issues raised.

HESI GTTC Survey Link:  https://www.surveymonkey.com/r/L627CBM

Sep 25
0

Paper in Mutagenesis: Extended treatment with recovery improves results in the peripheral blood lymphocyte micronucleus assay

By | Journals | No Comments

EDITOR’S CHOICE

Inclusion of an extended treatment with recovery improves the results for the human peripheral blood lymphocyte micronucleus assay

James Whitwell, Robert Smith, Teresa Chirom, Gary Watters, Victoria Hargreaves, Mel Lloyd, Sarah Phillips, Julie Clements

Mutagenesis, Volume 34, Issue 3, May 2019, Pages 217–237, https://doi.org/10.1093/mutage/gez011
Read the article here.
Aug 12
0

New Paper: Are All Bacterial Strains Required by OECD Needed?

By | Journals | No Comments

Are All Bacterial Strains Required by OECD Mutagenicity Test Guideline TG471 Needed?

Williams, Richard , DeMarini, David M. , et al Mutation Research/Genetic Toxicology and Environmental Mutagenesis August 2019

Read the latest paper in Mutation Research. Genetic Toxicology and Environmental Mutagenesis

Highlights

•Salmonella TA1535 detected few mutagens not detected by Salmonella TA100.
•Salmonella TA97 should be used in preference to Salmonella TA1537.
•Escherichia coli WP2 uvrA pKM101 is preferred to WP2 uvrA and Salmonella TA102.
•Salmonella TA98 & TA100 detected 93% of mutagens detected by all the TG471 strains.

DOI: 10.1016/j.mrgentox.2019.503081