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New Paper: Are All Bacterial Strains Required by OECD Needed?

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Are All Bacterial Strains Required by OECD Mutagenicity Test Guideline TG471 Needed?

Williams, Richard , DeMarini, David M. , et al Mutation Research/Genetic Toxicology and Environmental Mutagenesis August 2019

Read the latest paper in Mutation Research. Genetic Toxicology and Environmental Mutagenesis

Highlights

Salmonella TA1535 detected few mutagens not detected by Salmonella TA100.
Salmonella TA97 should be used in preference to Salmonella TA1537.
Escherichia coli WP2 uvrA pKM101 is preferred to WP2 uvrA and Salmonella TA102.
Salmonella TA98 & TA100 detected 93% of mutagens detected by all the TG471 strains.

DOI: 10.1016/j.mrgentox.2019.503081

Special Issue of Environmental and Molecular Mutagenesis

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See the latest issue from Environmental and Molecular Mutagenesis – Special Issue: Applied Genetic Toxicology: From Principles to Practice

Includes articles on mechanisms of DNA damage, repair and mutagenesis, next generation testing strategy for assessment of genomic damage, and reviews on regulatory requirements for geneotoxicity assessment. See the full Table of Contents and access the issue here:

http://onlinelibrary.wiley.com/doi/10.1002/em.v58.5/issuetoc?campaign=woletoc