Are All Bacterial Strains Required by OECD Mutagenicity Test Guideline TG471 Needed?
Mutation Research/Genetic Toxicology and Environmental Mutagenesis August 2019
Read the latest paper in Mutation Research. Genetic Toxicology and Environmental Mutagenesis
- •Salmonella TA1535 detected few mutagens not detected by Salmonella TA100.
- •Salmonella TA97 should be used in preference to Salmonella TA1537.
- •Escherichia coli WP2 uvrA pKM101 is preferred to WP2 uvrA and Salmonella TA102.
- •Salmonella TA98 & TA100 detected 93% of mutagens detected by all the TG471 strains.
New article ‘Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation’ by Ji and LeBaron has been published in Environmental and Molecular Mutagenesis. Read the article here
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Includes articles on mechanisms of DNA damage, repair and mutagenesis, next generation testing strategy for assessment of genomic damage, and reviews on regulatory requirements for geneotoxicity assessment. See the full Table of Contents and access the issue here: